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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Local Anesthetics: Chemistry and Structure-Activity Relationship01:30

Local Anesthetics: Chemistry and Structure-Activity Relationship

Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Updated: Jun 19, 2026

Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Semipermanent and permanent injectable fillers.

Derek H Jones1

  • 1Skin Care and Laser Physicians of Beverly Hills, 9201 W. Sunset Boulevard, Suite 602, Los Angeles, CA 90069, USA. derekjonesmd@gmail.com

Dermatologic Clinics
|October 24, 2009
PubMed
Summary
This summary is machine-generated.

Physicians have many injectable dermal filler options for facial augmentation in the U.S. These include semipermanent fillers like hyaluronic acid derivatives (HA) and permanent fillers such as polymethyl methacrylate microspheres (PMMA).

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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Dermatology and Aesthetic Medicine
  • Biomaterials Science

Background:

  • A wide range of injectable dermal fillers are now available for facial soft-tissue augmentation in the United States.
  • These agents have been developed and introduced within the last five years, offering diverse options.

Purpose of the Study:

  • To review the available categories of semipermanent and permanent injectable dermal fillers for facial augmentation.
  • To provide physicians with an overview of current filler technologies.

Main Methods:

  • Literature review of currently available injectable dermal fillers in the U.S. market.
  • Categorization of fillers based on longevity (semipermanent vs. permanent) and composition.

Main Results:

  • Semipermanent fillers include hyaluronic acid derivatives (HA), calcium hydroxylapatite (CaHA), and poly-L-lactic acid (PLA).
  • Permanent fillers include polymethyl methacrylate microspheres (PMMA), purified liquid silicone, and hydrogel polymers.

Conclusions:

  • Physicians have a broad selection of injectable dermal fillers with varying durations of effect.
  • Understanding the different filler categories and compositions is crucial for effective facial augmentation procedures.