Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).

The Journal of general physiology·2025
Same author

Evidence of a genetic background predisposing to complex regional pain syndrome type 1.

Journal of medical genetics·2023
Same author

Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies.

Brain : a journal of neurology·2023
Same author

Genome sequencing and comprehensive rare-variant analysis of 465 families with neurodevelopmental disorders.

American journal of human genetics·2023
Same author

Genetic pain loss disorders.

Nature reviews. Disease primers·2022
Same author

Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K<sub>V</sub>6.4 Subunit.

Cell reports·2020

Related Experiment Video

Updated: Jun 19, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Primary microcephaly: do all roads lead to Rome?

Gemma K Thornton1, C Geoffrey Woods

  • 1Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrookes Hospital, Cambridge, UK.

Trends in Genetics : TIG
|October 24, 2009
PubMed
Summary

Primary microcephaly (MCPH) studies reveal centrosomes are crucial for prenatal brain growth. MCPH proteins, linked to reduced brain size, unexpectedly gather at centrosomes, highlighting their role in neurogenesis regulation.

More Related Videos

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)
09:25

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers (MADM)

Published on: May 8, 2020

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
07:40

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Published on: April 14, 2017

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Human brain size and cerebral cortex expansion are unique evolutionary traits linked to adaptability.
  • Autosomal recessive primary microcephaly (MCPH) offers a model to study reduced prenatal brain growth.
  • Five MCPH genes have been identified, with their proteins localizing to centrosomes.

Purpose of the Study:

  • To investigate the role of Microcephaly (MCPH) proteins in prenatal neurogenesis.
  • To understand the function of centrosomes in the context of brain development disorders.

Main Methods:

  • Focus on recent functional studies of identified MCPH proteins.
  • Analysis of protein localization within the cell cycle.

Main Results:

  • All identified MCPH proteins are ubiquitously expressed.
  • MCPH proteins localize to centrosomes during at least part of the cell cycle.
  • Centrosomes act as a central hub for regulatory pathways impacting prenatal neurogenesis.

Conclusions:

  • The centrosome is a critical site for integrating signals regulating mammalian prenatal neurogenesis.
  • Understanding MCPH protein function at centrosomes is key to unraveling mechanisms of brain size control.