MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study.
Rocío Cupeiro1, Pedro J Benito, Nicola Maffulli
1Laboratory of Exercise Physiology, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain.
The Monocarboxylate Transporter 1 (MCT1) A1470T gene variant may impair lactate transport during high-intensity exercise. This genetic difference impacts lactate accumulation and maximal lactate levels in athletes, suggesting a role in exercise performance.
Area of Science:
- Exercise Physiology
- Human Genetics
- Sports Science
Background:
- Monocarboxylate Transporter 1 (MCT1) is crucial for sarcolemmal lactate transport.
- A common MCT1 A1470T polymorphism's effect on exercise performance is largely undefined.
Purpose of the Study:
- To investigate the influence of the MCT1 A1470T polymorphism (rs1049434) on lactate accumulation during high-intensity circuit training.
Main Methods:
- Ten young men performed controlled circuit training (CWT) at 60%, 70%, and 80% of 15RM.
- Lactate levels were measured post-set, analyzing MCT1 genotypes and training intensity.
Main Results:
- Lactate concentrations were significantly higher at 80% 15RM compared to lower intensities.
- Significant differences in lactate accumulation slope and maximal lactate (Lmax) were observed between MCT1 genotype groups at 80% 15RM.
Conclusions:
- Carriers of the MCT1 A1470T polymorphism may have reduced lactate transport capability.
- This genetic variant could negatively impact high-intensity exercise performance by affecting lactate shuttling for oxidation.
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