Occlusion of the left coronary trunk secondary to tertiary syphilis

Ricardo Wang1, Gustavo Blume, Newton Fernando Stadler Souza Filho

  • 1Hospital Santa Casa de Curitiba, Praça Rui Barbosa 245, Curitiba, Paraná, Brazil. rwang@cardiol.br

Insights

Tertiary syphilis can cause severe heart problems like coronary artery disease and unstable angina. This case highlights the importance of considering syphilis in cardiac diagnoses.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathology

Background:

  • Tertiary syphilis is a late stage of syphilis infection.
  • It can affect multiple organ systems, including the cardiovascular system.
  • Myocardial ischemia and coronary artery disease are rare but serious manifestations.

Observation:

  • A 27-year-old patient presented with symptoms of unstable angina.
  • The patient was diagnosed with tertiary syphilis.
  • The unstable angina was secondary to left coronary trunk occlusion.

Findings:

  • Diagnosis was confirmed through serological testing for syphilis.
  • Pathological assessment of an aorta fragment provided further evidence.
  • The findings linked tertiary syphilis directly to coronary artery occlusion.

Implications:

  • This case underscores the need for a broad differential diagnosis in patients with cardiac symptoms.
  • Early recognition and treatment of syphilis are crucial to prevent severe cardiovascular complications.
  • Highlights the importance of integrating infectious disease screening into cardiac workups.

Related Concept Videos

Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Coronary Circulation01:21

Coronary Circulation

The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...