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Related Experiment Video

Updated: Jun 19, 2026

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings
09:36

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Published on: February 3, 2021

Development of small and inexpensive digital data acquisition systems using a microcontroller-based approach.

Mark A Naivar1, Mark E Wilder, Robert C Habbersett

  • 1The National Flow Cytometry Resource, Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87131-0001, USA. naivar@darksim.com

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|October 24, 2009
PubMed
Summary
This summary is machine-generated.

A new digital flow cytometry data acquisition system uses a microcontroller for low-cost, high-precision analysis. This system demonstrates excellent sensitivity and resolution, suitable for various flow cytometry applications.

Related Experiment Videos

Last Updated: Jun 19, 2026

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings
09:36

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Published on: February 3, 2021

Area of Science:

  • Biotechnology
  • Instrumentation
  • Digital Signal Processing

Background:

  • Digital data acquisition systems enhance flexibility and precision in flow cytometry.
  • Existing systems can be costly and complex.

Purpose of the Study:

  • To develop a low-cost, small, and low-power digital flow cytometry data acquisition system.
  • To evaluate the system's performance and applicability in flow cytometry.

Main Methods:

  • Utilized a single microcontroller with an integrated analog-to-digital converter (ADC).
  • Integrated a commercially available evaluation board into the system.
  • Evaluated performance using calibration microspheres on commercial, slow-flow, and CCD-based flow cytometers.

Main Results:

  • The system successfully resolved all eight peaks of Rainbow microspheres on multiple cytometer types.
  • Demonstrated sensitivity and resolution suitable for most flow cytometry applications.
  • Achieved millisecond time resolution, full waveform collection, and selective CCD camera triggering.

Conclusions:

  • Microcontroller-based data acquisition offers a valuable approach for flow cytometry.
  • The system is suitable for extending the lifespan of older cytometers.
  • Presents a compelling design for low-cost, portable flow cytometry solutions.