Related Experiment Video
Updated: Jun 19, 2026

Microscopic Electric Rotary Grinding of Plaques Combined with Graft Repair in the Management of Peyronie's Disease
Published on: March 15, 2024
[Minute dose of tadalafil for nocturnal penile tumescence]
Fei Li1, Qi-Zhao Zhou, Tie-Qiu Li
1Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Objective:
To investigate the efficacy of tadalafil on nocturnal penile tumescence (NPT).
Methods:
Thirty-four patients with organic erectile dysfunction (ED) were treated with oral tadalafil at the dose of 10 mg/3 d before bedtime. A month later, 14 of the patients were observed for NPT by nocturnal electrobioimpedance volumetric assessment (NEVA).
Results:
The parameters of erectile function significantly improved in the 14 patients (P < 0.05).
Conclusion:
Oral administration of minute dose of tadalafil can improve NPT in organic ED patients.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Male Sexual Response: Erection & Ejaculation
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Dosage Regimens: Partial Pharmacokinetic Parameters
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship