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Updated: Jun 19, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Rapid maxillary expansion affects the spheno-occipital synchondrosis in youngsters. A study with low-dose computed
Rosalia Leonardi1, Alice Cutrera, Ersilia Barbato
1Department of Orthodontics, University of Catania, Catania, Italy. rleonard@unict.it
Objective:
To test the null hypothesis that the spheno-occipital synchondrosis does not show bony displacement in response to rapid maxillary expansion (RME) therapy in youngsters.
Materials And Methods:
A total of 16 computed tomography (CT) records were taken from 8 growing patients (2 males and 6 females), before (T0) and after (T1) treatment with RME. All patients had been diagnosed originally with transverse maxillary deficiency. The mean chronological age of the patients was 9.8 +/- 1.8 years (range, 8 to 11.4 years). High-resolution multislice multidetector CT was used to study quantitatively the extent of the opening of the spheno-occipital synchondrosis following RME. A low-dose CT scan protocol was used (80 kV, 10 mA) and the data file of each patient was transferred to a workstation where the anteroposterior width of the spheno-occipital synchondrosis was measured on axial images.
Results:
Before treatment with RME (T0), the anteroposterior mean width of the spheno-occipital synchondrosis was 1.73 +/- 0.46 mm immediately after the active phase of expansion (T1), and the width of the synchondrosis increased to 2.30 +/- 0.47. This difference was statistically significant according to the Wilcoxon signed rank test (P < .05).
Conclusion:
Rapid maxillary expansion leads to a small immediate widening of the spheno-occipital synchondrosis in youngsters.
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