Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Pharmacokinetics in Pediatric Patients: Drug Distribution

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

Nephrotic Syndrome II : Assessment and Medical Management

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PD-1 is requisite for skin T<sub>RM</sub> cell formation and specification by TGFβ.

Nature immunology·2025

Same author

Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis.

Nature reviews. Rheumatology·2024

Same author

Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale.

Arthritis care & research·2023

Same author

Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence·2023

Same author

Comparison of Biopsychosocial Characteristics of Children with Juvenile Idiopathic Arthritis According to Common Disease Subtypes.

Turkish archives of pediatrics·2023

Same author

Drug metabolism and inflammation related distinct miRNA signature of colchicine resistant familial Mediterranean fever patients.

International immunopharmacology·2023

Search research articles

Related Experiment Videos

Update in paediatric vasculitis.

Seza Ozen¹, Robert C Fuhlbrigge

¹Department of Pediatrics, Hacettepe University, Ankara, Turkey. sezaozen@hacettepe.edu.tr

Best Practice & Research. Clinical Rheumatology

|October 27, 2009

Summary

Vasculitis, inflammation of blood vessels, presents complex challenges in understanding and treatment. Recent updates focus on classifying childhood vasculitis and understanding its causes, paving the way for better research.

Area of Science:

Rheumatology
Pediatrics
Immunology

Background:

Vasculitis encompasses diverse disorders marked by blood vessel inflammation.
Despite research, fundamental mechanisms of systemic vasculitis initiation and progression are poorly understood.
Vasculitis poses significant challenges in classification, diagnosis, pathogenesis, and management.

Observation:

This review highlights recent proposed classification changes for pediatric vasculitis.
Advances in understanding the etiopathogenesis of vasculitis are discussed.

Findings:

Improved classification criteria for pediatric vasculitis are emerging.
New insights into the causes and development of vasculitis are being made.

Implications:

Related Experiment Videos

Enhanced classification of childhood vasculitis is expected to facilitate multicenter-controlled treatment studies.
Further research into vasculitis pathogenesis is crucial for improved clinical management.
Addressing knowledge gaps in vasculitis is vital for advancing pediatric rheumatology.