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Spontaneous remission in Cushing's disease
G Dickstein1, A Spindel, C Shechner
1Endocrine Division, Haifa (Israel) Medical Center.
Archives of Internal Medicine
|January 1, 1991
Summary
Spontaneous remission of Cushing's disease is possible, occurring in four patients within five years. This suggests that remission may not be as rare as previously thought, warranting further investigation into its incidence.
Area of Science:
- Endocrinology
- Internal Medicine
Background:
- Cushing's disease, a condition characterized by excessive cortisol production, typically requires intervention.
- Observational studies are crucial for understanding the natural course of endocrine disorders.
Observation:
- Eleven patients with Cushing's disease were monitored, with four experiencing spontaneous remission.
- Treatment modalities varied, including medication, surgery, and no intervention, allowing for diverse observations.
Findings:
- Spontaneous remission occurred between 9 months and 5 years post-diagnosis.
- Remission manifested as restored normal adrenal function or, in some cases, hypoadrenalism with addisonian crisis.
Implications:
- The findings suggest spontaneous remission in Cushing's disease may be underestimated.
- Further research is needed to determine the true incidence and predictors of spontaneous remission.