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Cytomegalovirus infection does not accelerate microvasculopathy development in heart transplant recipients

M Zakliczynski1, A Krynicka-Mazurek, D Konecka-Mrowka

  • 1Department of Cardiac Surgery & Transplantation, Silesian Center for Heart Diseases, Zabrze, Poland.

Transplantation Proceedings
|October 28, 2009
PubMed
Abstract

Insights

Cytomegalovirus (CMV) infection does not appear to promote microvasculopathy in heart transplant recipients. This study found no significant difference in microvasculopathy development between CMV-positive and CMV-negative patients.

Area of Science:

  • Cardiology
  • Transplantation immunology
  • Virology

Background:

  • Previous studies suggest cytomegalovirus (CMV) infection increases intimal hyperplasia in heart transplant recipients.
  • The impact of CMV on microvasculopathy development remains unclear.

Purpose of the Study:

  • To compare the incidence of microvasculopathy in endomyocardial biopsies (EMBs) of heart transplant recipients with and without CMV infection.

Main Methods:

  • A retrospective, case-controlled study of 58 CMV-infected patients (pp65 antigen positive) and 58 matched controls without CMV disease.
  • Microvasculopathy was assessed using a 4-grade system in EMBs at 1 and 12 months post-transplantation.

Main Results:

  • No significant differences in acute rejection episodes between CMV(+) and control groups at 1 or 12 months.
  • The most common microvasculopathy was nonstenotic thickening, with similar prevalence in both groups at 1 and 12 months.
  • No significant differences in microvasculopathy score progression or regression between groups from 1 to 12 months.

Conclusions:

  • The study's findings do not support the hypothesis that CMV infection promotes microvasculopathy development in heart transplant recipients.

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