Related Experiment Video
Updated: Jun 19, 2026
11:06
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Development and intra-institutional and inter-institutional validation of a comprehensive new hepatobiliary software:
Gerbail T Krishnamurthy1, Shakuntala Krishnamurthy, Sanjiv Sam Gambhir
1Department of Nuclear Medicine, Tuality Community Hospital, Hillsboro, Oregon 97123, USA. GTKrishna@aol.com
Nuclear Medicine Communications
|October 28, 2009
Summary
A new software tool for liver and gallbladder function quantification demonstrates promising repeatability and reproducibility. This nuclear hepatology tool may help standardize data acquisition and analysis across institutions.
Area of Science:
- Nuclear Medicine
- Medical Software Development
- Hepatobiliary Imaging
Background:
- Accurate quantification of liver and gallbladder function is crucial for diagnosing hepatobiliary disorders.
- Existing methods for assessing liver and gallbladder function may lack standardization and consistent reproducibility.
- Development of validated software tools is essential for improving the reliability of nuclear hepatology assessments.
Purpose of the Study:
- To develop and validate a software tool for quantifying liver and gallbladder function using 99mTc-iminodiacetic acid studies.
- To assess the intra-observer repeatability and inter-observer reproducibility of measurements obtained with the software.
- To evaluate the software's potential for standardizing data acquisition and analysis in nuclear hepatology.
Main Methods:
- A JAVA-based software tool was developed for analyzing 99mTc-iminodiacetic acid studies.
- Key parameters quantified include hepatic bile flow, hepatic extraction fraction (HEF), excretion half-time, basal and CCK-stimulated duodeno-gastric bile reflux (B-DGBR), gallbladder ejection fraction, ejection period (EP), and ejection rate (ER).
- Repeatability and reproducibility were assessed through intra-observer analysis in 10 participants and inter-site analysis in 24 participants across multiple centers.
Main Results:
- The software demonstrated high repeatability for most liver and gallbladder function parameters, including HEF and gallbladder ejection fraction.
- Marginal repeatability was observed for gallbladder bile flow, basal B-DGBR, and EP.
- High inter-observer concordance was found among primary center observers, with varying concordance across different institutions for specific parameters like basal B-DGBR, EP, and ER.
Conclusions:
- The developed Krishnamurthy Hepato-Biliary Software shows potential for consistent and reproducible quantification of liver and gallbladder function.
- The software may facilitate universal standardization of data acquisition and analysis in nuclear hepatology.
- Further validation across diverse clinical settings is recommended to fully establish its utility.
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