Related Experiment Video
Updated: Jun 19, 2026
08:55
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Update on emerging drugs for cancer cachexia
Kate T Murphy1, Gordon S Lynch
1Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Melbourne 3010, Australia.
Expert Opinion on Emerging Drugs
|October 29, 2009
Summary
Emerging drugs show promise for treating cancer cachexia, a syndrome of muscle wasting and weakness. Combined therapies targeting anorexia, inflammation, and muscle breakdown may offer the most effective treatment for this complex condition.
Area of Science:
- Oncology
- Metabolism
- Pharmacology
Background:
- Cancer cachexia is a debilitating syndrome characterized by progressive muscle wasting and weakness in cancer patients.
- This condition significantly impairs daily living, causes fatigue, reduces quality of life, and negatively impacts treatment response and survival.
- The multifactorial nature of cachexia involves anorexia, inflammation, metabolic disturbances, and enhanced muscle proteolysis, presenting multiple therapeutic targets.
Purpose of the Study:
- To provide an updated overview of emerging therapeutic agents for managing cancer cachexia.
- To highlight advancements in drug development aimed at combating the complex symptoms of cancer cachexia.
Main Methods:
- This study is a comprehensive review of the current landscape of emerging therapies for cancer cachexia.
- It synthesizes information on novel drug development and therapeutic strategies.
Main Results:
- Research is increasingly focused on developing innovative treatments for cancer cachexia.
- Therapeutic strategies have evolved from solely addressing anorexia to targeting inflammation and muscle proteolysis.
- Combination drug therapies are being explored to simultaneously address multiple facets of cachexia.
Conclusions:
- Several existing and novel drugs demonstrate potential for ameliorating cancer cachexia.
- The most effective treatment for cancer cachexia is likely to involve combination drug therapies targeting its various underlying mechanisms.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...