Related Experiment Video
Updated: Jun 19, 2026

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine
Published on: November 4, 2018
Progress towards liver and lung-directed gene therapy with helper-dependent adenoviral vectors
Nicola Brunetti-Pierri1, Philip Ng
1Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Avenue, Houston, TX 77030, USA.
Abstract:
Helper-dependent adenoviral vectors (HDAd) have several characteristics making them very attractive for human gene therapy. These vectors are completely devoid of viral coding sequences and are able to mediate high efficiency transduction in vivo to direct high level transgene expression with negligible chronic toxicity. Progress towards liver and lung directed gene therapy with HDAd as well as the current obstacles facing human applications and possible strategies to overcome these obstacles are discussed.
More Related Videos
09:13Study of Viral Vectors in a Three-dimensional Liver Model Repopulated with the Human Hepatocellular Carcinoma Cell Line HepG2
Published on: October 24, 2016
19:02High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors
Published on: March 22, 2011
Related Concept Videos
Gene Therapy
Gene Therapy
Microorganisms in Medicine and Therapeutics