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The PGC-1alpha-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
Antonella Cormio1, Flora Guerra, Gennaro Cormio
1Department of Biochemistry and Molecular Biology E. Quagliariello, University of Bari, Via Orabona, 4-70126 Bari, Italy. a.cormio@biologia.uniba.it
Abstract:
PGC-1alpha-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and in normal endometrium. In cancer endometrial tissue the citrate synthase activity, the mitochondrial DNA content and the TFAM level were found doubled compared to control endometrial tissue. Moreover, a 1.6- and 1.8-fold increase, respectively, of NRF-1 and PGG-1alpha expression was found. This study demonstrates, for the first time, that the increased mitochondrial biogenesis in type I endometrial cancer is associated to the upregulation of PGC-1alpha signalling pathway.
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