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Related Experiment Video

Updated: Jun 19, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al(2)O(3) laser source.

B Bouma, G J Tearney, S A Boppart

|October 29, 2009

Summary

This summary is machine-generated.

A novel Ti:Al(2)O(3) laser provides high-power, high-resolution imaging for optical coherence tomography. This technology achieves 3.7-mum resolution in biological tissues, enabling detailed in situ visualization.

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Last Updated: Jun 19, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

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Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography

Published on: January 15, 2013

Area of Science:

Biomedical Optics
Laser Physics
Medical Imaging Technology

Background:

Optical Coherence Tomography (OCT) is a crucial non-invasive imaging modality.
High-resolution OCT requires advanced light sources with specific characteristics.
Titanium-sapphire (Ti:Al(2)O(3)) lasers are known for their broad tunability and ultrashort pulse generation.

Purpose of the Study:

To develop a high-power laser source for enhanced resolution in OCT.
To optimize a Kerr-lens mode-locked Ti:Al(2)O(3) oscillator for OCT applications.
To demonstrate the capability of the developed laser for high-resolution in situ imaging of biological tissues.

Main Methods:

Utilized a Kerr-lens mode-locked Ti:Al(2)O(3) oscillator engineered for minimal coherence length.
Implemented dispersion compensation techniques to manage pulse broadening.
Employed heterodyne noise rejection methods to improve signal-to-noise ratio.
Performed in situ imaging of biological tissue samples.

Main Results:

Achieved an imaging resolution of 3.7 micrometers.
Demonstrated a dynamic range of 93 dB for the OCT system.
Successfully obtained high-quality in situ images of biological tissues.
The optimized laser source proved effective for high-resolution OCT.

Conclusions:

A Kerr-lens mode-locked Ti:Al(2)O(3) oscillator is a viable high-power source for high-resolution OCT.
Dispersion compensation and heterodyne noise rejection are critical for achieving superior imaging performance.
The demonstrated system offers significant potential for advanced biological tissue imaging.