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Updated: Jun 19, 2026
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Postdural puncture headache in complex regional pain syndrome: a retrospective observational study
Alexander G Munts1, Joan H C Voormolen, Johan Marinus
1Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Objective:
To describe the unusual course of postdural puncture headache (PDPH) after pump implantation for intrathecal baclofen (ITB) administration in patients with complex regional pain syndrome (CRPS)-related dystonia.
Design:
Case series based on data collected from 1996 to 2005. Setting. Movement disorders clinic, university hospital.
Patients:
A total of 54 patients with CRPS-related dystonia who were treated with ITB.
Results:
A high incidence (76%) and prolonged course (median 18 days, range 2 days to 36 months) of PDPH was found. Radionuclide studies performed in two patients with long-lasting symptoms (12-16 months) did not reveal cerebrospinal fluid (CSF) leakage. In patients without signs of CSF leakage (N = 38), epidural blood patches administered in 24 patients were effective in 54%, while ketamine infusions administered in six patients were effective in 67%.
Conclusions:
Our observations may suggest that other mechanisms besides intracranial hypotension play a role in the initiation and maintenance of PDPH in CRPS and stimulate new directions of research on this topic.
