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Updated: Aug 15, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
Treatment of unstable bladder
1Department of Urology, University of California School of Medicine, San Francisco.
Abstract:
We present our experience with 2 spinal-injury patients tested for urinary incontinence via implanted sacral nerve electrodes. In each patient, spinal injury occurred at the T-12 level, with presentation of spontaneous detrusor activity. Associated weakness of the voluntary sphincter mechanism was evident urodynamically. Neurostimulation via wire electrode in the S3 foramen produced good sphincter closure. Voiding secondary to spontaneous detrusor triggering could thereby be suppressed, eliminating embarrassing incontinence without interfering with the patient's ability to empty the bladder at regular intervals. The therapeutic principles of neurostimulation applicable to patients with spastic bladders are underscored by these 2 cases.
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