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Updated: Jun 19, 2026
10:49
Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Doxycline-induced esophageal ulcerations.
M A Al Mofarreh1, I A Al Mofleh
1Department of Gastroenterology, Dr. Al Mofarreh Polyclinic, King Fahd Quarters, Riyadh, Saudi Arabia.
Summary
Oral doxycycline taken at bedtime with minimal water can cause esophageal ulcerations. Symptoms often resolve quickly with treatment, even if doxycycline continues.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Drug-induced esophageal injury is a recognized clinical issue.
- Doxycycline is a common antibiotic with potential gastrointestinal side effects.
Purpose of the Study:
- To investigate the role of oral doxycycline in causing esophageal ulcerations.
- To identify risk factors associated with doxycycline-induced esophageal injury.
Main Methods:
- Retrospective analysis of 16 patients presenting with drug-induced esophageal ulcerations.
- Clinical data including symptoms, timing of drug intake, and endoscopic findings were reviewed.
Main Results:
- 13 patients with doxycycline-induced esophageal ulcerations were analyzed.
- Common symptoms included odynophagia, retrosternal pain, and dysphagia.
- Ulcers were located in the mid-esophagus; symptoms resolved within a week of treatment.
Conclusions:
- Oral doxycycline intake, particularly at bedtime with insufficient water, is a significant cause of esophageal ulcerations.
- Antireflux treatment is effective, and doxycycline can often be continued safely.
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