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A Silver Nanoparticle Method for Ameliorating Biliary Atresia Syndrome in Mice
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Antimicrobial efficacy and ocular cell toxicity from silver nanoparticles.

Colleen M Santoro1, Nicole L Duchsherer, David W Grainger

  • 1Cell and Molecular Biology Program, Colorado State University, Ft. Collins, CO 80523-1872 USA.

Nanobiotechnology : the Journal at the Intersection of Nanotechnology, Molecular Biology, and Biomedical Sciences
|October 30, 2009
PubMed
Summary

Silver nanoparticles show potential for contact lens drug delivery, but current loadings do not yield sufficient antimicrobial silver ion release. Higher nanoparticle concentrations may be needed for effective bacterial control in extended-wear lenses.

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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
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Published on: April 21, 2023

Area of Science:

  • Ophthalmology
  • Nanotechnology
  • Microbiology

Background:

  • Silver possesses known antimicrobial properties beneficial for biomedical applications.
  • Ocular drug delivery faces challenges due to rapid clearance, reducing efficacy and potentially causing systemic side effects.

Purpose of the Study:

  • To investigate silver nanoparticles (AgNPs) as a controlled-release source of antimicrobial silver for contact lens formulations.
  • To evaluate the antimicrobial efficacy and safety of AgNPs in vitro for ocular applications.

Main Methods:

  • Assessed in vitro silver ion release from various AgNP sizes and doses over several weeks.
  • Tested antimicrobial activity against Pseudomonas aeruginosa (PA01).
  • Evaluated mammalian cell viability and cytokine expression using corneal epithelial cells and macrophages.

Main Results:

  • Minimal microcidal and cell toxic effects were observed at tested AgNP concentrations.
  • Insufficient silver ion release was detected to cause significant biological effects in vitro.
  • Silver particles themselves were not microcidal under the tested conditions.

Conclusions:

  • Current AgNP loadings in contact lenses do not provide sufficient antimicrobial silver ion release for efficacy.
  • Increased AgNP loading in lenses may be necessary to achieve bactericidal effects against bacterial colonization.
  • AgNPs offer a potential strategy for managing bacterial issues in extended-wear contact lenses if loading is optimized.