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Related Experiment Videos

Methotrexate-induced asthma.

G Jones1, E Mierins, J Karsh

  • 1Department of Medicine, University of Ottawa, Ontario, Canada.

The American Review of Respiratory Disease
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Methotrexate therapy for rheumatoid arthritis can cause asthma-like symptoms. Adjusting the dosage interval to 10 days resolved the pulmonary issues, demonstrating a link between methotrexate and airway hyperreactivity.

Area of Science:

  • Rheumatology
  • Pulmonology
  • Clinical Pharmacology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Methotrexate is a common disease-modifying antirheumatic drug (DMARD) used in RA treatment.
  • Adverse pulmonary events are a known, albeit rare, complication of methotrexate therapy.

Observation:

  • A patient with rheumatoid arthritis experienced new-onset asthma symptoms and abnormal pulmonary function tests during methotrexate treatment.
  • Airway hyperreactivity was documented via methacholine challenge testing while the patient was on methotrexate.
  • These pulmonary findings resolved upon discontinuation of methotrexate therapy.

Findings:

  • Methotrexate-induced airway hyperreactivity was observed in this patient.

Related Experiment Videos

  • Extending the methotrexate dosage interval from 7 to 10 days led to complete resolution of asthma symptoms.
  • The asthma remained in remission even after resuming a weekly dosing schedule, suggesting a sustained effect from the modified interval.

    • Implications:

    • This case highlights the importance of considering methotrexate-induced pulmonary complications in RA patients presenting with respiratory symptoms.
    • Modifying the methotrexate dosing schedule, specifically extending the interval, may be an effective strategy to manage or prevent methotrexate-induced asthma.
    • Further investigation into the mechanisms of methotrexate-induced airway hyperreactivity and the efficacy of altered dosing regimens is warranted.