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Related Experiment Videos

Developmental changes in pleural liquid protein concentration in sheep.

V C Broaddus1, M Araya, D P Carlton

  • 1Department of Medicine, San Francisco General Hospital, CA 94110.

The American Review of Respiratory Disease
|January 1, 1991
PubMed
Summary

Pleural fluid in sheep originates from the systemic circulation, not the lungs. This is supported by decreasing pleural fluid protein concentration relative to plasma during development, correlating with rising systemic vascular pressure.

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Area of Science:

  • Physiology
  • Developmental Biology
  • Cardiovascular System

Background:

  • The origin of normal pleural liquid is debated, with theories suggesting either systemic or pulmonary circulation.
  • Evidence suggests a systemic origin due to low pleural fluid protein concentration in adults, consistent with high-pressure circulation sieving.
  • Systemic vascular pressure increases during development, prompting investigation into its effect on pleural fluid composition.

Purpose of the Study:

  • To test the hypothesis that pleural fluid originates from the systemic circulation.
  • To determine if pleural fluid protein concentration relative to plasma decreases with age during development.

Main Methods:

  • Collected pleural liquid and plasma from fetal, newborn, and adult sheep (n=14, 9, 15, respectively).

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  • Measured total protein and albumin concentrations in pleural liquid and plasma.
  • Measured systemic and pulmonary arterial pressures in age-matched sheep.

    • Main Results:

    • Pleural fluid/plasma protein concentration progressively decreased with age (fetuses: 0.50±0.15; newborns: 0.27±0.08; adults: 0.15±0.05).
    • Pleural fluid/plasma albumin ratios showed a similar age-related decrease.
    • Systemic arterial pressure increased with age, while pulmonary arterial pressure decreased.

    Conclusions:

    • Findings support the hypothesis that normal pleural liquid originates from the systemic circulation.
    • Developmental changes in vascular pressure influence pleural fluid composition.
    • The study provides evidence for a systemic source of pleural fluid in sheep.