Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intracellular Movement of Viruses and Bacteria

Intracellular Movement of Viruses and Bacteria

Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a virus that...

Bacterial Phylum Chlamydiae

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...

Bacterial Phylum Spirochaetes

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...

Colonisation of Pathogens

Colonisation of Pathogens

Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

Bacterial Phylum Actinobacteria

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

Fimbriae, Pili, and Axial Filaments

Fimbriae, Pili, and Axial Filaments

Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Dysentery Bacillus in a Series of Cases of Infantile Diarrhea.

The Journal of medical research·2009

Same author

THE BACTERIOLOGY OE BRONCHO- AND LOBULAR PNEUMONIA IN INFANCY.

The Journal of experimental medicine·2009

Same author

A STUDY OF THE BACTERIOLOGY OF PERTUSSIS, WITH SPECIAL REFERENCE TO THE AGGLUTINATION OF THE PATIENT'S BLOOD.

The Journal of experimental medicine·2009

Same author

THE INFLUENZA BACILLUS IN INFLAMMATIONS OF THE RESPIRATORY TRACT IN INFANTS.

The Journal of experimental medicine·2009

Same author

A BIOLOGICAL STUDY OF THE CEREBRO-SPINAL FLUID IN ANTERIOR POLIOMYELITIS.

The Journal of experimental medicine·2009

Same author

THE BORDET-GENGOU BACILLUS OF PERTUSSIS.

The Journal of experimental medicine·2009

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

BIOLOGICAL RELATIONSHIPS OF DIPLOCOCCUS INTRACELLULARIS AND GONOCOCCUS.

¹Rockefeller Institute for Medical Research, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Gonococcus and Diplococcus intracellulans share similar pathogenic effects and immune responses, despite cultural differences. Both bacteria lose virulence rapidly upon artificial cultivation, indicating shared biological characteristics.

More Related Videos

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Published on: August 5, 2020

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Related Experiment Videos

Last Updated: Jun 19, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

Published on: February 8, 2019

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Kinetic Visualization of Single-Cell Interspecies Bacterial Interactions

Published on: August 5, 2020

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

Area of Science:

Microbiology
Immunology
Bacteriology

Background:

Gonococcus and Diplococcus intracellulans are Gram-negative cocci.
Understanding their differences and similarities is crucial for diagnostics and treatment.

Purpose of the Study:

To compare the cultural, pathogenic, and immunological characteristics of gonococcus and Diplococcus intracellulans.
To investigate shared immune responses between these two bacterial species.

Main Methods:

Comparative analysis of cultural growth patterns and media preferences.
Assessment of pathogenicity in guinea-pig models.
Evaluation of immune responses (agglutinins, aggressins, protective power, amboceptors) in immunized animal sera.

Main Results:

Significant cultural differences exist, primarily in growth abundance and media choice.
Both bacteria require larger doses to induce lethality in guinea pigs, with similar lesion development.
Pathogenic power diminishes rapidly with artificial cultivation for both species.
Immune factors like agglutinins and protective power are largely common to gonococcus and Diplococcus intracellulans.
No shared receptors were found with other Gram-negative cocci or Streptococcus pyogenes.

Conclusions:

Gonococcus and Diplococcus intracellulans exhibit substantial overlap in pathogenicity and immune system interactions.
Cultural distinctiveness does not fully translate to divergent immunological profiles.
These findings suggest potential cross-reactivity in immune responses, impacting vaccine development and diagnostics.