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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

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Published on: February 22, 2019

THE BORDET-GENGOU BACILLUS OF PERTUSSIS.

¹Rockefeller Institute for Medical Research, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

The Bordet-Gengou bacillus is found in early pertussis cases but is hard to isolate after two weeks. This study supports it as a pertussis cause, though new evidence is limited.

Area of Science:

Microbiology
Infectious Diseases
Immunology

Background:

Pertussis, or whooping cough, is a respiratory infection.
The causative agent of pertussis has been debated, with Bordet-Gengou bacillus and influenza bacillus as candidates.
Understanding the pathogen is crucial for diagnosis and treatment.

Purpose of the Study:

To investigate the role of Bordet-Gengou bacillus in pertussis.
To compare the presence and characteristics of Bordet-Gengou bacillus and influenza bacillus in pertussis patients.
To explore immune responses to these bacteria in pertussis.

Main Methods:

Bacteriological examination of sputum from pertussis patients.
Isolation and identification of Bordet-Gengou bacillus and influenza bacillus.

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Serological tests, including agglutinin and complement deviation tests, using patient and rabbit sera.

Main Results:

Bordet-Gengou bacillus is present in early pertussis sputum and lungs in fatal cases, but difficult to isolate after two weeks.
Influenza bacillus is found early and persists longer in sputum than Bordet-Gengou bacillus.
Agglutinin levels and complement deviation tests showed differences between the two bacteria, but patient serum results were inconclusive for Bordet-Gengou bacillus.

Conclusions:

The study provides supporting evidence for Bordet-Gengou bacillus as a potential cause of pertussis.
While the bacillus's dissemination in nature and occurrence in pertussis are confirmed, distinct new evidence is lacking.
Further research on bronchial secretions in other respiratory diseases is recommended.