Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Experimental agglutinative and hemolytic Transfusions.

The Journal of medical research·2009
Same author

Studies in experimental Transfusion.

The Journal of medical research·2009
Same author

STUDIES IN ISOAGGLUTINATION : II. THE OCCURRENCE OF GROUPED ISOAGGLUTINATION IN THE LOWER ANIMALS.

The Journal of experimental medicine·2009
Same author

STUDIES IN ISOAGGLUTINATION : III. TONICITY IN ISOHEMAGGLUTINATION.

The Journal of experimental medicine·2009
Same author

THE ISOELECTRIC ZONE OF TYPHOID AGGLUTININ.

The Journal of general physiology·2009
Same author

The Treatment of Hemolytic Streptococcus Infections and the Newer Applications of Sulphanilamide.

Bulletin of the New York Academy of Medicine·2009
Same journal

Regulation of solid tumors by the peripheral nervous system.

The Journal of experimental medicine·2026
Same journal

Friend or foe? IFNλ drives fibrosis.

The Journal of experimental medicine·2026
Same journal

BAd-looking or CHarming: The two faces of BACH2.

The Journal of experimental medicine·2026
Same journal

Bridging veins govern discrepancy of CSF efflux into dura mater in mice.

The Journal of experimental medicine·2026
Same journal

Chimeric allergen receptor regulatory T cells suppress birch pollen allergic airway inflammation.

The Journal of experimental medicine·2026
Same journal

Interferon-λ drives renal fibrosis by coordinating epithelial-fibroblast crosstalk.

The Journal of experimental medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Determining the Reactivity and Titre of Serum using a Haemagglutination Assay
05:59

Determining the Reactivity and Titre of Serum using a Haemagglutination Assay

Published on: January 29, 2010

STUDIES IN ISOAGGLUTINATION : I. TRANSFUSION AND THE QUESTION OF INTRAVASCULAR AGGLUTINATION.

R Ottenberg1

  • 1Pathological Laboratory of Mount Sinai Hospital and the Laboratory of Biological Chemistry of Columbia University, College of Physicians and Surgeons, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Transfusion agglutination can cause severe reactions or death, but is often prevented by factors like agglutinin concentration and cell types. Pre-transfusion testing is crucial for patient safety.

More Related Videos

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Related Experiment Videos

Last Updated: Jun 19, 2026

Determining the Reactivity and Titre of Serum using a Haemagglutination Assay
05:59

Determining the Reactivity and Titre of Serum using a Haemagglutination Assay

Published on: January 29, 2010

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
06:34

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

Published on: December 1, 2017

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Intravascular agglutination is a potential risk following blood transfusions.
  • This phenomenon can lead to severe adverse events, including death, or may occur asymptomatically.
  • Several factors influence the occurrence and severity of transfusion agglutination.

Purpose of the Study:

  • To elucidate the factors influencing intravascular agglutination after blood transfusion.
  • To provide guidance on donor selection when compatible blood is unavailable.
  • To emphasize the importance of pre-transfusion compatibility testing.

Main Methods:

  • Analysis of factors affecting agglutination: agglutinin concentration, absorption by agglutinable cells, and interference by non-agglutinable cells.
  • Evaluation of donor selection strategies in non-ideal compatibility scenarios.
  • Discussion of pre-transfusion testing protocols versus transfusion necessity.

Main Results:

  • Agglutination severity depends on agglutinin concentration, absorption capacity of patient's cells, and presence of non-agglutinable cells.
  • In cases of incompatibility, using a donor whose serum agglutinates the patient's cells is safer than using a donor whose cells are agglutinated by the patient's serum.
  • Transfused agglutinable cells are phagocytosed, limiting long-term benefits even without immediate adverse reactions.

Conclusions:

  • Understanding the dynamics of agglutination is key to preventing transfusion complications.
  • Strategic donor selection can mitigate risks when perfect matches are unavailable.
  • Pre-transfusion testing for agglutination and hemolysis is essential, with careful risk-benefit assessment when immediate transfusion is critical.