A STUDY OF CULTURES FROM SPUTUM AND BLOOD IN LOBAR PNEUMONIA

T W Hastings1, E Boehm

  • 1Laboratory of Clinical Pathology of Cornell University Medical College, New York.

Insights

Pneumococcus was found in 30.3% of blood cultures from pneumonia patients, with a 60% mortality rate in these cases. Sputum cultures showed pneumococci in 54% of pneumonia cases studied between 1910-1912.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pulmonary Medicine

Background:

  • Bacterial pneumonia remains a significant cause of morbidity and mortality.
  • Accurate and timely diagnosis is crucial for effective treatment of pneumonia.
  • Identifying the causative pathogen, particularly Streptococcus pneumoniae, aids in prognosis and management.

Purpose of the Study:

  • To investigate the incidence of pneumococci in blood and sputum cultures of pneumonia patients.
  • To correlate the presence of pneumococci with patient outcomes, specifically mortality.
  • To compare the diagnostic yield of blood versus sputum cultures for identifying pneumonia pathogens.

Main Methods:

  • Collected blood and sputum cultures from 32 unselected pneumonia cases.
  • Performed microbiological analysis to identify bacterial pathogens.
  • Correlated culture results with patient survival and mortality data.

Main Results:

  • Pneumococcus was detected in 30.3% of all blood cultures (10 out of 33).
  • Of patients with pneumococcus in blood cultures, 60% (6 out of 10) died.
  • Sputum cultures from 1910-1912 revealed pneumococci in 54% of pneumonia cases.

Conclusions:

  • Blood cultures are valuable for identifying pneumococcus in pneumonia, with a significant association with mortality.
  • Sputum culture findings suggest a high prevalence of pneumococci in pneumonia cases during the study period.
  • Further research into diagnostic markers and therapeutic interventions for pneumococcal pneumonia is warranted.

Related Concept Videos

Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture01:26

Sputum Studies I: Gram Stain, cytology, and Acid-fast smear and culture

Sputum studies are a critical part of diagnosing and treating numerous respiratory conditions. These studies involve obtaining sputum samples for analysis to identify pathogenic organisms and assess the presence of abnormal cells indicative of malignant conditions. This lesson will delve into three fundamental sputum studies: Gram Stain, Cytology, and Acid-fast Smear and Culture.
Gram Stain
The Gram Stain is an integral part of sputum studies. It involves the staining of sputum, which permits...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...