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Published on: January 13, 2016
A STUDY OF CULTURES FROM SPUTUM AND BLOOD IN LOBAR PNEUMONIA
1Laboratory of Clinical Pathology of Cornell University Medical College, New York.
Abstract:
In the thirty-two unselected cases studied, cultures were taken from both the blood and the sputum, and in five of these more than one blood culture was taken. In one case the culture was taken from the blood only, and in this instance the pneumococcus was found. This case will be considered only with reference to the incidence of the pneumococci in blood cultures in lobar pneumonia. The results in the thirty-two cases in which cultures were made both from the blood and the sputum are as follows: 1. In eleven cases the blood and sputum cultures were positive. (a) In nine cases the pneumococcus was isolated, and five of these patients died. (b) In two cases, instead of the pneumococcus, Streptococcus hemolysans (longus) was found. One of these patients died. 2. In twenty-one cases the blood cultures were negative, and in eighteen of these the sputum cultures were positive and in three negative. In these three the only result recorded was the absence of the pneumococcus. (a) In nine cases the pneumococcus was isolated. Two of these patients died. (b) In twelve cases no pneumococcus was found. Two of these patients died. Of the patients in which no pneumococcus was found, in two cases Bacillus coli was isolated; in one case Micrococcus catarrhalis; in one case a staphylococcus (type not stated); in two cases staphylococcus and streptococcus; in one case Bacillus influenzae, in one case Bacillus fluorescens non-liquefaciens; in one case an unidentified Gram positive chromogenic organism, probably saprophytic; and in three cases there are no recorded results except that the pneumococcus was absent. In the total of thirty-three blood cultures, the pneumococcus was found in ten cases (30.3 per cent.), and six of the patients died. During the years 1910 to 1912 sputum cultures were taken from forty-four cases of pneumonia, of which twenty-four showed pneumococci (54 per cent.), and twenty showed no pneumococci (45 per cent.).
Insights
Pneumococcus was found in 30.3% of blood cultures from pneumonia patients, with a 60% mortality rate in these cases. Sputum cultures showed pneumococci in 54% of pneumonia cases studied between 1910-1912.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pulmonary Medicine
Background:
- Bacterial pneumonia remains a significant cause of morbidity and mortality.
- Accurate and timely diagnosis is crucial for effective treatment of pneumonia.
- Identifying the causative pathogen, particularly Streptococcus pneumoniae, aids in prognosis and management.
Purpose of the Study:
- To investigate the incidence of pneumococci in blood and sputum cultures of pneumonia patients.
- To correlate the presence of pneumococci with patient outcomes, specifically mortality.
- To compare the diagnostic yield of blood versus sputum cultures for identifying pneumonia pathogens.
Main Methods:
- Collected blood and sputum cultures from 32 unselected pneumonia cases.
- Performed microbiological analysis to identify bacterial pathogens.
- Correlated culture results with patient survival and mortality data.
Main Results:
- Pneumococcus was detected in 30.3% of all blood cultures (10 out of 33).
- Of patients with pneumococcus in blood cultures, 60% (6 out of 10) died.
- Sputum cultures from 1910-1912 revealed pneumococci in 54% of pneumonia cases.
Conclusions:
- Blood cultures are valuable for identifying pneumococcus in pneumonia, with a significant association with mortality.
- Sputum culture findings suggest a high prevalence of pneumococci in pneumonia cases during the study period.
- Further research into diagnostic markers and therapeutic interventions for pneumococcal pneumonia is warranted.
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