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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
Published on: January 29, 2014
COMPLEMENT FIXATION TESTS IN CHRONIC INFECTIVE DEFORMING ARTHRITIS AND ARTHRITIS DEFORMANS.
1Department of Clinical Pathology of Cornell University Medical College, and The Second Medical Division of Bellevue Hospital, New York.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Streptococcus viridans is identified as a probable cause of arthritis deformans, potentially responsible for over 40% of cases. Gonococcus infection is a rare cause, even when present latently.
Area of Science:
- Rheumatology
- Infectious Diseases
- Immunology
Background:
- Arthritis deformans is a debilitating condition with unclear etiology.
- Identifying infectious agents is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the role of Streptococcus viridans and Neisseria gonorrhoeae in the pathogenesis of arthritis deformans.
- To determine the prevalence of these infections as causative agents in arthritis deformans.
Main Methods:
- Comparative analysis of patient data with control groups.
- Utilized complement fixation tests to detect immune responses to specific pathogens.
- Evaluated clinical manifestations in relation to identified infections.
Main Results:
- Streptococcus viridans was confirmed as an infectious agent, eliciting a complement-fixing substance in arthritis deformans patients.
- Over 40% of arthritis deformans cases are likely attributable to chronic infective deforming arthritis caused by Streptococcus viridans.
- Gonococcus infection rarely causes arthritis deformans, despite its high incidence and potential co-occurrence with Streptococcus viridans.
Conclusions:
- Streptococcus viridans is a probable primary causative agent in a significant proportion of arthritis deformans cases.
- Chronic infective deforming arthritis should be considered in the differential diagnosis.
- While gonococcus can be present, it is an infrequent cause of arthritis deformans clinical manifestations.
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