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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
A CONTRIBUTION TO THE RELATION BETWEEN PROTEID CLEAVAGE PRODUCTS AND ANAPHYLAXIS
1Departments of Physiology and Pharmacology and of Chemistry of The Rockefeller Institute for Medical Research, New York.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Anaphylactic lung research found no evidence of increased protein breakdown products. This study does not support the theory that protein split products cause anaphylactic lung conditions in guinea pigs.
Area of Science:
- Biochemistry
- Immunology
- Pathology
Background:
- Anaphylaxis is a severe allergic reaction.
- The pathophysiology of the anaphylactic lung is not fully understood.
- Previous hypotheses suggested a role for protein breakdown products.
Purpose of the Study:
- To investigate the presence of proteid cleavage products in the anaphylactic lung.
- To evaluate the validity of the hypothesis linking protein split products to anaphylactic lung conditions.
Main Methods:
- Utilized Van Slyke's amino nitrogen method for biochemical analysis.
- Examined lung tissue from guinea pigs experiencing anaphylaxis.
Main Results:
- No evidence of elevated proteid cleavage products was detected in the anaphylactic lung.
- Biochemical analysis did not reveal increased levels of protein breakdown products.
Conclusions:
- The findings do not support the hypothesis that protein split products cause the anaphylactic lung.
- Further research is needed to elucidate the exact mechanisms of anaphylactic lung injury.
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