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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Mechanisms of Retrovirus-induced Cancers

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

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Related Experiment Video

Updated: Jun 19, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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THE IMMUNOLOGICAL RELATIONS OF THE ROUS CHICKEN SARCOMA.

¹Columbia University, George Crocker Special Research Fund, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Injecting chicken embryo extract does not prevent Rous chicken sarcoma development. Chickens inoculated with the sarcoma 5 to 100 days after treatment showed no resistance, indicating this method is ineffective for cancer prevention.

Area of Science:

Oncology
Virology
Immunology

Background:

Rous chicken sarcoma is a neoplastic disease affecting chickens.
Investigating methods to confer resistance against viral-induced tumors is crucial in veterinary oncology.
Previous studies explored various immunotherapeutic approaches for avian cancers.

Purpose of the Study:

To determine if chicken embryo extract injections provide resistance against Rous chicken sarcoma.
To evaluate the efficacy of this treatment across different post-injection inoculation periods.

Main Methods:

Chickens received injections of chicken embryo extract (1-10 cc).
Following treatment, chickens were inoculated with Rous chicken sarcoma at intervals of 5 to 100 days.
Tumor development was monitored to assess resistance.

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Main Results:

Injections of chicken embryo extract did not confer any resistance to Rous chicken sarcoma.
Sarcoma inoculation at all tested time points (5-100 days post-treatment) resulted in tumor development.
No significant difference in tumor incidence was observed between treated and control groups (implied).

Conclusions:

Chicken embryo extract is not an effective prophylactic agent against Rous chicken sarcoma.
The findings suggest that this specific treatment does not induce protective immunity or anti-tumor responses in chickens.
Further research may be needed to explore alternative immunomodulatory strategies for avian viral tumors.