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Related Experiment Video

Updated: Jun 19, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

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INTRATESTICULAR IMPLANTATION OF THE FLEXNER-JOBLING RAT CARCINOMA.

W H Woglom1

  • 1Columbia University, George Crocker Special Research Fund, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

The Flexner-Jobling adenocarcinoma, a rat cancer, grows smaller in the testis than under the skin. This size difference is not just due to pressure, suggesting other unknown factors influence tumor growth.

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RESISTANCE PRODUCED IN MICE AGAINST TRANSPLANTED CANCER BY AUTO-INOCULATION OF THE SPLEEN.

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THE DURATION AND EXTENT OF INDUCED RESISTANCE TOWARD TUMOR TRANSPLANTATION IN MICE.

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THE IMMUNOLOGICAL RELATIONS OF THE ROUS CHICKEN SARCOMA.

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DIET AND TUMOR GROWTH.

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A PYOGENIC FILTERABLE AGENT IN THE ALBINO RAT.

The Journal of experimental medicine·2009

Area of Science:

  • Oncology
  • Comparative Pathology
  • Animal Models

Background:

  • The Flexner-Jobling adenocarcinoma is a well-characterized rat tumor model.
  • Intratesticular transplantation is a method used to study tumor behavior in specific microenvironments.

Purpose of the Study:

  • To investigate the growth characteristics of Flexner-Jobling adenocarcinoma when transplanted into the rat testis.
  • To compare the size of intratesticular tumors with subcutaneous tumors.

Main Methods:

  • Transplantation of Flexner-Jobling adenocarcinoma cells into the intact rat testis.
  • Monitoring and measurement of tumor growth.
  • Comparison of tumor sizes between intratesticular and subcutaneous locations.

Main Results:

  • Flexner-Jobling adenocarcinoma is readily transplantable into the rat testis.
  • Tumors grown within the testis are generally smaller than those grown subcutaneously.
  • The reduced size of intratesticular tumors cannot be fully attributed to physical pressure alone.

Conclusions:

  • The rat testis provides a unique microenvironment that restricts tumor growth.
  • Factors beyond mechanical pressure influence the growth of intratesticular tumors.
  • Further research is needed to identify the specific factors limiting tumor size in the testicular microenvironment.

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