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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 19, 2026

A Protocol for Housing Mice in an Enriched Environment
09:30

A Protocol for Housing Mice in an Enriched Environment

Published on: June 8, 2015

DIET AND TUMOR GROWTH.

W H Woglom1

  • 1Columbia University, George Crocker Special Research Fund, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Lactose consumption does not enhance tumor growth in mice and rats. This study found no evidence that lactose increases susceptibility to transplantable carcinomata in these species.

Area of Science:

  • Oncology
  • Animal Models
  • Nutrition

Background:

  • The role of dietary factors in cancer progression is a significant area of research.
  • Lactose, a primary sugar in milk, has been investigated for various biological effects.

Purpose of the Study:

  • To determine if lactose intake influences the susceptibility of rodents to experimentally induced tumors.
  • To investigate the potential of lactose as a promoter of carcinomata in mice and rats.

Main Methods:

  • Mice and rats were administered lactose.
  • Transplantable carcinomata were introduced to the study subjects.
  • Tumor development and growth were monitored.

Main Results:

  • Lactose administration did not lead to an increased incidence or growth rate of transplantable carcinomata in mice.

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  • Similarly, lactose did not enhance the receptivity of rats to these carcinomata.
  • No statistically significant difference in tumor progression was observed between lactose-fed and control groups.

    • Conclusions:

    • Lactose does not appear to increase the susceptibility of mice and rats to transplantable carcinomata.
    • Dietary lactose is unlikely to be a significant factor in the progression of these specific tumor models.