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EXPERIMENTS ON THE CAUSATION AND AMELIORATION OF ADRENALIN PULMONARY EDEMA
1Department of Physiology and Pharmacology of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Adrenalin injection causes pulmonary edema in rabbits with divided vagi, but artificial respiration and atropine offer protection. This suggests lung alveolar aspiration plays a key role in adrenalin-induced pulmonary edema.
Area of Science:
- Pulmonary Medicine
- Cardiovascular Physiology
- Pharmacology
Background:
- Epinephrine (adrenalin) can induce pulmonary edema.
- The role of the vagus nerve and respiratory mechanics in this process is not fully understood.
Purpose of the Study:
- To investigate the mechanism of adrenalin-induced pulmonary edema in rabbits.
- To evaluate the protective effects of artificial respiration and atropine.
Main Methods:
- Intratracheal injection of adrenalin in rabbits with divided vagi and in normal rabbits.
- Administration of artificial respiration and atropine.
- Observation of pulmonary edema, cardiac function, and tracheal stenosis effects.
Main Results:
- Divided vagi significantly increased adrenalin-induced pulmonary edema.
- Artificial respiration markedly reduced edema in vagotomized rabbits.
- Tracheal stenosis facilitated edema.
- Adrenalin caused ventricular incoordination, lung hyperemia, and hemorrhage.
- Atropine demonstrated a protective effect against edema.
Conclusions:
- Alveolar aspiration is a key mechanism in adrenalin pulmonary edema, particularly after vagotomy.
- Artificial respiration mitigates this edema by counteracting aspiration.
- Atropine provides a protective effect, possibly by influencing autonomic pathways.
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