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II. RENAL FUNCTION INFLUENCED BY PROTEOSE INTOXICATION.

I McQuarrie1, G H Whipple

  • 1The George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Toxic proteose from intestinal obstruction impairs kidney function, reducing excretion of waste products like urea and salts. This temporary kidney cell injury resolves completely after intoxication ceases.

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Toxicology

Background:

  • Intestinal obstruction can lead to systemic intoxication.
  • Previous reports suggest renal function impairment during intestinal obstruction.

Purpose of the Study:

  • To investigate the effect of toxic proteose from obstructed small intestine on kidney function.
  • To determine if this impairment is due to direct kidney cell injury.

Main Methods:

  • Injection of toxic proteose into experimental subjects.
  • Assessment of kidney's excretory capacity for urea, sodium chloride, and phenolsulfonephthalein.
  • Control experiments with large fluid/solute loads and other proteose preparations.

Main Results:

  • Toxic proteose significantly decreased kidney excretion of urea, sodium chloride, and phenolsulfonephthalein.
  • Renal function impairment persisted even with direct intravenous administration of excretory substances.
  • No significant renal impairment observed with other proteose preparations.

Conclusions:

  • Toxic proteose from intestinal obstruction causes temporary, functionally significant kidney injury.
  • The injury appears to be at the kidney cell level, independent of major extrarenal factors.
  • Renal function recovers completely without anatomical damage upon resolution of intoxication.