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EXPERIMENTAL MUMPS MENINGITIS

M Wollstein1

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Researchers induced aseptic meningitis in cats using sterile saliva filtrate from parotitis cases. This meningitis, characterized by a favorable prognosis, was transmissible via cerebrospinal fluid, which remained bacteria-free.

Area of Science:

  • Veterinary Neurology
  • Infectious Diseases
  • Pathology

Background:

  • Parotitis, or mumps, can cause neurological complications.
  • Aseptic meningitis is inflammation of the meninges not caused by bacterial infection.
  • Understanding the transmission and etiology of meningitis is crucial for animal health.

Purpose of the Study:

  • To investigate the potential for inducing aseptic meningitis in cats.
  • To determine if the induced meningitis is transmissible between feline subjects.
  • To identify the causative agent of this experimentally induced meningitis.

Main Methods:

  • Intrathecal injection of sterile saliva filtrate from early parotitis cases in cats.
  • Subsequent injection of cerebrospinal fluid from affected cats into naive cats.
  • Bacteriological culture of cerebrospinal fluid to assess for microbial presence.

Main Results:

  • Aseptic meningitis with a 3-5 day duration and favorable prognosis was successfully induced in cats.
  • The induced meningitis was transmissible to other cats via cerebrospinal fluid.
  • Cerebrospinal fluid samples remained consistently bacteria-free throughout the study.

Conclusions:

  • Sterile saliva filtrate from parotitis cases can induce transmissible aseptic meningitis in cats.
  • The causative agent is non-bacterial and likely viral or other acellular infectious agent.
  • This model provides insights into the pathogenesis of certain types of meningitis.

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