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Updated: Jun 19, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

FAT METABOLISM IN NEPHRITIS.

A Hiller¹, G C Linder, C Lundsgaard

¹Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Nephritic patients with high blood lipids can efficiently metabolize fat. However, fat accumulation in their blood may stem from impaired lipid transfer to tissues.

Area of Science:

Biochemistry
Physiology
Nephrology

Background:

Kidney disease (nephritis) can affect lipid metabolism.
Understanding how nephritic patients handle dietary fat is crucial.

Purpose of the Study:

To compare fat metabolism in nephritic patients and healthy individuals.
To investigate the role of plasma lipids in nephritic fat processing.

Main Methods:

Measured plasma lipids, respiratory quotient, and total metabolism (Tissot method).
Administered a standardized high-fat meal (1 gm/kg body weight).
Compared pre- and post-meal measurements in nephritic and normal subjects.

Main Results:

Nephritics with high baseline blood lipids showed greater increases in plasma fatty acids and lecithin after fat intake compared to controls.

Related Experiment Videos

Last Updated: Jun 19, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

No significant differences in cholesterol levels were observed.

Nephritic patients with constant lipemia demonstrated normal fat-burning capacity.

Conclusions:

Nephritic patients with lipemia can efficiently utilize dietary fat.
Elevated blood lipids in these patients may result from a disrupted lipid transport mechanism to tissue storage sites.