Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Introductory lecture on the production and pathogenesis of experimental hypertension.

Annals of the New York Academy of Sciences·2010

Same author

The reciprocal relationship of surface temperature and time in the production of hyperthermic cutaneous injury.

The American journal of pathology·2010

Same author

Studies of thermal injury; an exploration of the casualty-producing attributes of conflagrations; local and systemic effects of general cutaneous exposure to excessive circumambient (air) and circumradiant heat of varying duration and intensity.

Archives of pathology·2010

Same author

Studies of thermal injury: hyperpotassemia caused by cutaneous exposure to excessive heat.

The Journal of clinical investigation·2010

Same author

Studies of thermal injury: physiological mechanisms responsible for death during cutaneous exposure to excessive heat.

The Journal of clinical investigation·2010

Same author

Sudden and unexpected deaths of young soldiers; diseases responsible for such deaths during World War II.

Archives of pathology·2010

Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026

Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026

Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026

Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026

Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026

Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

EXPERIMENTAL RICKETS IN RABBITS.

H Goldblatt¹, A R Moritz

¹Department of Pathology of the School of Medicine, Western Reserve University, Cleveland.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Rickets was experimentally induced in rabbits using diets low in the antirachitic factor and phosphorus. Cod liver oil supplementation effectively prevented rickets development in these rabbits.

More Related Videos

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Preclinical Model of Hind Limb Ischemia in Diabetic Rabbits

Published on: June 2, 2019

Area of Science:

Nutritional science
Biochemistry
Animal models in research

Background:

Rickets is a condition affecting bone development, particularly in young animals.
Dietary imbalances in essential nutrients like phosphorus and specific organic factors are implicated in rickets.
Calcium-phosphorus homeostasis is critical for skeletal health.

Purpose of the Study:

To investigate the experimental induction of rickets in rabbits.
To determine the efficacy of cod liver oil in preventing diet-induced rickets.

Main Methods:

Rickets was induced in rabbits through controlled diets deficient in the antirachitic organic factor and phosphorus.
These diets were characterized by a high calcium content.
Cod liver oil was administered as a dietary supplement to a subset of rabbits.

Main Results:

Experimental rickets was successfully produced in rabbits by manipulating dietary intake.
Rabbits receiving diets deficient in the antirachitic factor and phosphorus developed rickets.
The addition of cod liver oil to the rickets-producing diet completely prevented the onset of rickets.

Conclusions:

The antirachitic organic factor and phosphorus are essential for preventing rickets in rabbits.
Cod liver oil contains a potent factor that prevents experimental rickets.
Dietary management is crucial for preventing and potentially treating rickets.