MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE : X. THE RELATIVE SUSCEPTIBILITY OF DIFFERENT STRAINS OF MICE TO PER OS INFECTION WITH THE TYPE II BACILLUS OF MOUSE TYPHOID (BACILLUS PESTIS CAVLAE). FURTHER STUDIES
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1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
Four separate strains of mice have been tested for their relative susceptibility to per os infection with the Type II bacillus of mouse typhoid (Bacillus pestis caviae), 300 to 600 individuals of each strain having been employed in the course of 12 months. In confirmation of a previous paper, clear-cut differences in the susceptibility of these strains have been shown to exist. In general, the colored strains were distinctly less resistant than the albino strains.
Insights
Mouse typhoid susceptibility varies significantly between different mouse strains. Colored mouse strains demonstrated lower resistance to oral infection compared to albino strains in this study.
Area of Science:
- Immunology
- Microbiology
- Genetics
Background:
- Mouse typhoid is a significant disease in laboratory settings.
- Understanding host susceptibility is crucial for experimental design and animal welfare.
- Previous research indicated strain-specific differences in disease resistance.
Purpose of the Study:
- To investigate the relative susceptibility of four distinct mouse strains to oral infection with Bacillus pestis caviae (Type II mouse typhoid bacillus).
- To confirm and expand upon previous findings regarding strain-specific resistance.
- To identify potential genetic or phenotypic factors influencing resistance to mouse typhoid.
Main Methods:
- Oral inoculation of 300-600 mice per strain with Bacillus pestis caviae over 12 months.
- Observation and recording of infection outcomes and mortality rates.
- Comparative analysis of susceptibility across different mouse strains.
Main Results:
- Significant differences in susceptibility to per os infection were observed among the four tested mouse strains.
- Colored mouse strains exhibited markedly lower resistance to Bacillus pestis caviae infection compared to albino strains.
- These findings corroborate earlier studies on mouse strain variability in disease resistance.
Conclusions:
- Mouse strain genetics play a critical role in determining susceptibility to Bacillus pestis caviae infection.
- Albino mouse strains generally possess higher resistance to mouse typhoid than colored strains.
- Further research into the mechanisms underlying this differential resistance is warranted.
