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Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
Published on: March 7, 2011
INFLUENCE OF LIGHT ON THE GROWTH AND MALIGNANCY OF A TRANSPLANTABLE NEOPLASM OF THE RABBIT
1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
An experiment is reported in which an environment of constant and continuous light excluding the shorter ultra-violet rays, and one of constant darkness, have influenced the course and character of a malignant disease of rabbits induced by a transplantable neoplasm. Under the influence of constant light the level of malignancy was observed to be low; under the influence of constant darkness the level of malignancy was somewhat lower than in the control animals living under ordinary indoor light conditions, but the level was not as low as among the animals constantly illuminated. These observations furnish experimental evidence in support of the idea that there is a correlation between the external factor of light on the one hand and the manifestations of an experimental malignant disease on the other.

