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Related Concept Videos

Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Plague01:24

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...

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GIANT CELLS IN CULTURES FROM HUMAN LYMPH NODES.

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Application of CRISPR Interference (CRISPRi) for Gene Silencing in Pathogenic Species of Leptospira
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Application of CRISPR Interference (CRISPRi) for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

BACTERIUM LEPISEPTICUM INFECTION : ITS MODE OF SPREAD AND CONTROL.

L T Webster1, C Burn

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Host susceptibility, influenced by genetics and environment, drives disease spread. Enhancing resistance and reducing microbial dosage are key to preventing epidemics and controlling infections.

Area of Science:

  • Epidemiology
  • Infectious Disease Control

Background:

  • Endemic respiratory infections are influenced by host susceptibility.
  • Host susceptibility is determined by hereditary and environmental factors.
  • Microbial dosage in a population correlates with disease prevalence and severity.

Purpose of the Study:

  • To describe the spread of an endemic respiratory infection.
  • To propose and validate methods for infection control.
  • To highlight the role of host susceptibility in disease dynamics.

Main Methods:

  • Observational study of disease transmission in a rabbit population.
  • Implementation of strategies to enhance host resistance and reduce microbial dosage.
  • Review of experimental epidemiology studies on animal models.

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Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
10:47

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Published on: July 1, 2011

Related Experiment Videos

Last Updated: Jun 19, 2026

Application of CRISPR Interference (CRISPRi) for Gene Silencing in Pathogenic Species of Leptospira
14:49

Application of CRISPR Interference (CRISPRi) for Gene Silencing in Pathogenic Species of Leptospira

Published on: August 14, 2021

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice
10:32

Optimized Protocols for Mycobacterium leprae Strain Management: Frozen Stock Preservation and Maintenance in Athymic Nude Mice

Published on: March 23, 2014

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins
10:47

Immuno-fluorescence Assay of Leptospiral Surface-exposed Proteins

Published on: July 1, 2011

Main Results:

  • Successful control of Bact. lepisepticum infection in a rabbit population for three years.
  • Demonstrated correlation between population susceptibility, microbial dosage, and infection spread/severity.
  • Supported by findings from studies on rabbit and guinea pig respiratory epidemics.

Conclusions:

  • Host susceptibility is the primary determinant of endemic disease prevalence.
  • Preventing epidemics requires enhancing population resistance and minimizing microbial dosage.
  • Experimental epidemiology findings are applicable to human disease control.