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MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE. II
1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
1. Six strains of paratyphoid-enteritidis bacilli, isolated from man and animals, differed markedly in virulence for mice. 2. The inherent virulence of each strain for mice was not affected by repeated intraperitoneal and per os mouse passage. 3. Individual differences in the susceptibility of the mice to each strain and to graded doses of mercury bichloride were demonstrable. Such variations appear to be of a non-specific nature.
Insights
Six strains of paratyphoid-enteritidis bacilli showed varying virulence in mice, which remained consistent despite passage. Mouse susceptibility to these bacteria and mercury bichloride varied non-specifically.
Area of Science:
- Microbiology
- Immunology
- Animal Models
Background:
- Paratyphoid-enteritidis bacilli are significant pathogens in both human and animal health.
- Understanding strain-specific virulence is crucial for disease control and prevention strategies.
Purpose of the Study:
- To investigate the virulence of different paratyphoid-enteritidis bacilli strains in a mouse model.
- To determine if experimental passage affects bacterial virulence.
- To assess host susceptibility variations to bacterial infection and a chemical agent.
Main Methods:
- Six distinct strains of paratyphoid-enteritidis bacilli were isolated from human and animal sources.
- Virulence was assessed in mice through standardized infection protocols.
- Repeated intraperitoneal and oral passages were performed to evaluate strain stability.
- Mouse susceptibility was tested against graded doses of mercury bichloride.
Main Results:
- Significant differences in virulence were observed among the six paratyphoid-enteritidis bacilli strains when tested in mice.
- Repeated mouse passage, both intraperitoneal and oral, did not alter the inherent virulence of any tested strain.
- Individual mice exhibited demonstrable variations in susceptibility to both the bacterial strains and mercury bichloride.
Conclusions:
- The virulence of paratyphoid-enteritidis bacilli strains is an inherent characteristic not readily modified by experimental passage in mice.
- Host susceptibility to these bacteria and mercury bichloride appears to be influenced by non-specific factors, suggesting a complex interplay between pathogen and host.
