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MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN MOUSE TYPHOID INFECTION
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Mouse typhoid infection susceptibility varies among mice. Most mice succumb to Bacillus pestis caviae, while a small percentage recover or show no infection, indicating graded resistance.
Area of Science:
- Immunology
- Microbiology
- Infectious Diseases
Background:
- Mouse typhoid, caused by Bacillus pestis caviae, affects mice differently.
- Understanding host susceptibility is crucial for disease research.
Purpose of the Study:
- To analyze the graded variation in mouse susceptibility to Bacillus pestis caviae.
- To determine the virulence stability of the bacterial strain over time.
Main Methods:
- Infection of mice per os with a fixed dose of Bacillus pestis caviae.
- Monitoring for signs of infection, positive blood cultures, and agglutinins.
- Assessing bacterial virulence through various culture methods (blood, stool, septicemia).
Main Results:
- 20-30% of mice showed no infection.
- 5-10% of mice recovered from infection.
- 70-80% of mice succumbed to infection.
- The Bacillus pestis caviae strain maintained consistent virulence over 10 months.
Conclusions:
- Mouse susceptibility to Bacillus pestis caviae infection is graded.
- The bacterial strain's virulence remained stable throughout the experimental period.
