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Published on: March 25, 2020
VARIATIONS IN THE PLASMA CHOLESTEROL AND CHOLESTEROL ESTER CONTENT IN HOG CHOLERA
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Hog cholera (hog cholera virus) infection in swine causes unique, alternating changes in plasma cholesterol levels, shifting between hypocholesterolemia and hypercholesterolemia. This pattern differs from other acute infections and impacts cholesterol response to secondary infections.
Area of Science:
- Veterinary Medicine
- Infectious Diseases
- Biochemistry
Background:
- Plasma cholesterol levels in swine are significantly altered during hog cholera infection.
- Understanding these lipid profile changes is crucial for managing the disease and its complications.
Purpose of the Study:
- To investigate the dynamic changes in plasma cholesterol and cholesterol ester content in swine experimentally infected with hog cholera virus.
- To compare the observed cholesterol fluctuations in hog cholera with those in other acute infections.
Main Methods:
- Experimental inoculation of swine with hog cholera virus.
- Regular monitoring and measurement of plasma cholesterol and cholesterol ester levels throughout the disease course.
- Comparison of cholesterol profiles in infected swine with those of normal swine and swine infected with Bacillus suisepticus.
Main Results:
- Hog cholera infection induces a distinct pattern of plasma cholesterol changes: initial hypocholesterolemia, followed by hypercholesterolemia coinciding with clinical signs, and subsequent prolonged hypocholesterolemia.
- Swine infected with hog cholera showed a blunted hypocholesterolemic response when subsequently inoculated with Bacillus suisepticus, unlike normal swine.
- The observed alternating hypocholesterolemia and hypercholesterolemia in hog cholera is unique among acute infections studied.
Conclusions:
- Hog cholera virus infection causes a unique and complex dyslipidemia in swine.
- The altered cholesterol metabolism during hog cholera may influence the host's response to secondary bacterial infections.
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