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Published on: December 4, 2015
STUDIES ON IMMUNITY TO SWINE INFLUENZA.
1Department of Animal and Plant Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
The swine influenza virus, not the bacteria, provides immunity against swine influenza. Administering the virus intramuscularly prevents illness and confers protection, suggesting a respiratory tract infection link.
Area of Science:
- Veterinary Virology
- Bacteriology
- Immunology
Background:
- Swine influenza is caused by two etiological components.
- Understanding the roles of each component is crucial for disease control.
Purpose of the Study:
- To determine which etiological component of swine influenza possesses immunizing properties.
- To investigate the role of each component in disease production and immunity.
Main Methods:
- Administration of swine influenza virus intramuscularly.
- Testing the immunizing properties of the filtrable virus and H. influenzae suis.
- Neutralization assays using serum from convalescent swine.
Main Results:
- Only the filtrable virus demonstrated immunizing properties.
- H. influenzae suis was essential for disease but did not confer immunity alone.
- Serum from convalescent swine neutralized both the organism and virus.
- Intramuscular swine influenza virus induced immunity without causing illness.
Conclusions:
- The swine influenza virus is the primary etiological agent responsible for immunity.
- H. influenzae suis plays a secondary, contributory role in swine influenza pathogenesis.
- A specific infectivity relationship likely exists between swine influenza virus and respiratory tract tissues.
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