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Nasal Wipes for Influenza A Virus Detection and Isolation from Swine
Published on: December 4, 2015
SWINE INFLUENZA : III. FILTRATION EXPERIMENTS AND ETIOLOGY.
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Swine influenza requires both a specific virus and Haemophilus influenzae suis to cause disease. Immunity develops after infection, and the virus can be preserved for future studies.
Area of Science:
- Veterinary Virology
- Microbiology
- Infectious Diseases
Background:
- Swine influenza is a significant respiratory disease in pigs.
- The causative agent and its pathogenesis have been areas of research interest.
Purpose of the Study:
- To identify and characterize the viral agent of swine influenza.
- To elucidate the etiological role of Haemophilus influenzae suis.
- To understand the synergistic interaction between the virus and bacteria in disease causation.
Main Methods:
- Isolation and intranasal inoculation of a filtrable virus from swine influenza cases.
- Co-administration of the virus with Haemophilus influenzae suis cultures.
- Clinical and pathological assessment of induced disease in swine.
- In vitro neutralization assays using immune serum.
Main Results:
- A filtrable virus was isolated that caused mild respiratory illness alone.
- Co-infection with the virus and H. influenzae suis resulted in disease identical to natural swine influenza.
- Immunity was conferred by one infection, with serum neutralizing infectious material.
- The virus demonstrated stability in dried form and glycerol for several weeks.
Conclusions:
- Swine influenza is a co-infection requiring both a specific virus and H. influenzae suis.
- Immunity to swine influenza is demonstrable and can be passively transferred via serum.
- The findings highlight similarities between swine and human influenza.
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