Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Patterns of Fever

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.

American Trypanosomiasis

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

Toxoplasmosis

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...

Yellow Fever

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...

Plague

Plague

Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acute Respiratory Infections.

War medicine (Paris, France)·2023

Same author

A Study of the Diphtheria Group of Organisms; with Special reference to Fermentation Reactions.

The Journal of medical research·2009

Same author

On the Precipitation of bacterial extracts by extracts of Leucocytes.

The Journal of medical research·2009

Same author

Observations on the Mechanism of Protection by Leucocyte extracts.

The Journal of medical research·2009

Same author

A Report of twenty-four Cases of Epidemic Meningitis treated with Leucocyte extract.

The Journal of medical research·2009

Same author

On the Treatment of lobar Pneumonia with Leucocyte extract.

The Journal of medical research·2009

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

STUDIES ON MEXICAN TYPHUS FEVER. I.

H Zinsser¹, A P Batchelder

¹Department of Bacteriology and Immunology of the Harvard University Medical School, Boston.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This study investigates typhus fever, finding the virus is likely smaller than bacteria and not filterable. It associates closely with red blood cells and can be maintained in tissue culture and guinea pigs.

Area of Science:

Microbiology
Virology
Immunology

Background:

Previous studies on typhus fever primarily used a Mexican strain.
Fundamental problems of typhus fever require reinvestigation.

Purpose of the Study:

To investigate the fundamental properties of the typhus fever virus.
To determine the filterability, cellular association, and survival of the typhus virus.
To explore immunological responses and potential for active immunization.

Main Methods:

Filtration experiments using standard virological techniques.
Tissue culture for virus survival studies.
Inoculation of guinea pigs to assess virulence and testicular lesions.
Analysis of convalescent blood and serum for protective antibodies.

More Related Videos

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Published on: December 28, 2018

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Related Experiment Videos

Last Updated: Jun 19, 2026

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Raising the Mexican Tetra Astyanax mexicanus for Analysis of Post-larval Phenotypes and Whole-mount Immunohistochemistry

Published on: December 28, 2018

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Active immunization trials with formalinized viral material.

Main Results:

The typhus virus is not filterable by conventional methods and is likely smaller than bacteria.
The virus associates with red blood cells but is not contained within them.
The virus remains viable in tissue culture and guinea pig peritoneum for approximately 10 days.
Testicular swelling in guinea pigs is characteristic but can be variable.
Convalescent blood shows protective properties up to ten days post-defervescence.
Active immunization with formalinized material showed protective effects.

Conclusions:

The findings suggest the Mooser bodies observed in Mexican typhus guinea pigs represent the disease's virus.
The virus's non-filterable nature and association with blood cells provide insights into its transmission.
Further immunological studies are warranted, particularly regarding protective antibodies and active immunization.