EXPERIMENTAL NEPHRITIS IN THE FROG : I. THE ANATOMICAL EVIDENCE OF DAMAGE

1. The damage produced by corrosive sublimate, potassium bichromate and uranium nitrate in the frog's kidney is described. 2. The morphological lesions consist of evidences of tubular damage, such as regressive changes in the epithelium, and of damage to the glomeruli ranging from increase in their permeability to gross damage of and hemorrhage from the tuft. 3. The point is emphasized that these lesions differ in their degree rather than in their nature from those found in the mammalian kidney after the administration of the same poisons. 4. The frog's kidney is exceptionally well suited therefore for the study of lesions which though present are masked in the complexities of structure and function of the mammalian kidney.