Related Experiment Video
Updated: Jun 19, 2026

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
Published on: February 24, 2014
A NOTE ON THE SPECIFIC AGGLUTINATION OF PNEUMOCOCCUS TYPES I, II AND III
1Department of Bacteriology and Immunology, Harvard University Medical School, Boston.
Abstract:
1. Type-specific agglutination of Pneumococcus Types I, II and III has been demonstrated in antisera largely deprived of the carbohydrate antibody. 2. The type-specific agglutinogens in Pneumococcus I and II responsible for agglutination in such antisera are inactivated by heating in alkaline solution at 100 degrees C. The specific carbohydrate remains unaltered under these conditions. 3. The relationship of the type-specific agglutinogen in Pneurmococcus I to the type-specific A substance has been discussed. 4. The possible application of these results to the standardization of therapeutic antisera by agglutinin titre has been discussed. 5. On the basis of the experiments recorded a tentative explanation is offered for the failure of Pneumococcus Type II to absorb the agglutinins from anti-B. friedlaenderi Type B serum.
Related Concept Videos
Atypical Pneumonia
Pneumonia III: Complications and Assessment
Pneumonia I: Introduction
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Bacterial Meningitis II: Pathophysiology
Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...

