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STUDIES ON THE NATURE OF THE AGENT TRANSMITTING LEUCOSIS OF FOWLS : II. FILTRATION OF LEUCEMIC PLASMA
1The Henry Phipps Institute, University of Pennsylvania, Philadelphia.
The Journal of Experimental Medicine
|October 30, 2009
Summary
The agent causing leucosis can pass through filters, but filtration slightly reduces its concentration. This agent is smaller than bovine pleuropneumonia virus, similar in size to bacteriophage.
Area of Science:
- Veterinary virology
- Filtration science
Background:
- Leucosis is a disease caused by a transmissible agent in plasma.
- Understanding the physical properties of this agent is crucial for disease control.
Purpose of the Study:
- To determine the filterability of the leucosis agent.
- To estimate the size of the leucosis agent relative to known viruses.
Main Methods:
- Filtration of plasma using various siliceous filters (coarse and fine).
- Filtration using collodion membranes.
- Comparison of incubation periods post-filtration.
Main Results:
- The leucosis agent readily passed through siliceous filters.
- Pre-filtration through coarse filters improved fine filter efficacy.
- Filtration led to slightly prolonged incubation periods, indicating reduced agent concentration.
- The agent's size is smaller than bovine pleuropneumonia virus (250 mµ) and similar to bacteriophage.
Conclusions:
- The leucosis agent exhibits properties consistent with a small, filterable entity.
- Filtration can reduce the concentration of the infectious agent.
- The agent's size suggests it may be viral or sub-viral.
