THE RECOGNITION AND COMPARISON OF PROLAN AND PROLAN-LIKE SUBSTANCES
H M Evans1, M E Simpson, P R Austin
1Laboratories of The Rockefeller Institute for Medical Research, New York, and the University of California, Berkeley.
Abstract:
The synergism phenomenon has made possible the recognition of substances, which we have called "prolan-like," in a wide variety of conditions. Indeed, it has been possible to demonstrate a prolan-like material in the urine of normal men. The method has shown a wide distribution of prolan-like substances in sera and urines of non-primates without demonstrating, however, significant difference in the reactions secured from pregnant as contrasted with non-pregnant states, or in males as contrasted with females. The synergism phenomenon with pregnancy prolan can also be shown in the increased development of the seminal vesicles of immature male rats. However, such males cannot be advantageously employed in the detection of prolan-like gonadotropic substances occurring in the blood and urine in conditions other than pregnancy, for the prolan-like substances usually do not effect appreciable development of the seminal vesicles.
Related Concept Videos
¹H NMR Chemical Shift Equivalence: Homotopic and Heterotopic Protons
Prochirality
¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
Conformations of Ethane and Propane
Staggered conformation is a low energy and more stable conformation with the C-H bonds on the front carbon placed at 60°dihedral angles relative to the C-H bonds on the back carbon, leading to a reduced torsional strain. In staggered ethane, the...
Nomenclature of Alkanes
The alkane nomenclature considers the length of the carbon chain, the number, and the location of the substituent to arrive at its systematic name. The IUPAC...
Constitutional Isomers of Alkanes
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the branched isomers are given...


