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Related Experiment Video

Updated: Jun 19, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

AN INVESTIGATION OF THE ETIOLOGY OF MUMPS.

C D Johnson¹, E W Goodpasture

¹Department of Pathology, Vanderbilt University Medical School, Nashville.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Researchers isolated a novel virus from mumps patients' saliva. This filterable virus caused parotitis in monkeys, suggesting it is the causative agent of mumps.

Area of Science:

Virology
Infectious Diseases
Epidemiology

Background:

Mumps is a contagious viral illness characterized by swelling of the salivary glands.
The specific causative agent of mumps had not been definitively identified prior to this study.

Purpose of the Study:

To identify and isolate the infectious agent responsible for mumps.
To experimentally induce mumps-like symptoms in a susceptible animal model.

Main Methods:

Saliva samples were collected from patients in the early stages of mumps.
A filterable virus was isolated from positive samples.
The isolated virus was inoculated into the parotid glands of rhesus monkeys via Stensen's duct.

Main Results:

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Published on: September 7, 2022

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Last Updated: Jun 19, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

A filterable, cytotropic virus was successfully isolated from 4 out of 6 mumps patient saliva specimens.
Inoculation of rhesus monkeys resulted in acute, non-suppurative parotitis, clinically analogous to human mumps.
The isolated virus was free of detectable microorganisms and did not correspond to known viruses.

Conclusions:

The isolated filterable virus is identified as the causative agent of mumps.
This discovery provides a critical step in understanding mumps pathogenesis and developing diagnostic tools.