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Updated: Jun 19, 2026

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
Published on: August 19, 2016
THE TOXIC PROPERTIES OF SERUM EXTRACTS OF HEMOLYTIC STREPTOCOCCI
1Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.
Abstract:
1. A method is described whereby toxic substances may be extracted from hemolytic streptococci with inactivated serum. 2. Such extracts contain large amounts of hemotoxin and leucocidin. 3. Their intravenous injection into mice causes marked hemoglobinuria, anemia, and death. 4. There is evidence that this anemia is not the only cause of death of these animals. 5. Incomplete work seems to indicate that the hemotoxin and the lethal poisons are not antigenic. 6. Certain biological properties of the extract are described.
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